Human TENM2 Protein 2877

Additional Information:
accession Q9NT68|express systemHEK293|product tagN-His|purity> 90% as determined by Tris-Bis PAGE|backgroundTeneurin-2 is a member of a novel family of transmembrane proteins characterized to date in fish, birds, mammals, and Drosophila (e.g., the pair-rule gene product Ten-m). Teneurin-2, a vertebrate homologue of the Drosophila pair-rule gene ten-m/odz, is revealed to be a membrane-bound transcription regulator. In the nucleus, the intracellular domain of teneurin-2 colocalizes with promyelocytic leukemia (PML) protein in nuclear bodies implicated in transcription control.|molecular weightThe protein has a predicted MW of 48.48 kDa. The protein cleaved to 55-65 kDa, 38-43 kDa and 25-30 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human TENM2 Protein 2877proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceTeneurin-2 is a member of a novel family of transmembrane proteins characterized to date in fish, birds, mammals, and Drosophila (e.g., the pair-rule gene product Ten-m). Teneurin-2, a vertebrate homologue of the Drosophila pair-rule gene ten-m/odz, is revealed to be a membrane-bound transcription regulator. In the nucleus, the intracellular domain of teneurin-2 colocalizes with promyelocytic leukemia (PML) protein in nuclear bodies implicated in transcription control.Protein namesTeneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)]Gene namesTENM2,TENM2 KIAA1127 ODZ2 TNM2Protein familyTenascin family, Teneurin subfamilyMass9606DaFunctionInvolved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer.; [Isoform 2]: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion.; [Ten-2 intracellular domain]: Induces gene transcription inhibition.Subellular locationCell membrane ; Single-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Synapse. Cell projection, dendritic spine. Cell projection, filopodium. Cell projection, growth cone. Postsynaptic cell membrane ; Single-pass membrane protein. Synapse, synaptosome. Note=Colocalizes with ADGRL1 across intercellular junctions.; [Isoform 2]: Cell membrane. Note=Colocalizes with ADGRL1 across intercellular junctions.; [Ten-2 intracellular domain]: Nucleus, PML body .TissuesHighly expressed in heart, followed by brain, liver, kidney and fetal brain and weakly expressed in lung and testis. No expression was detected in skeletal muscle, pancreas, spleen, ovary and fetal liver.StructureHomodimer; disulfide-linked (Probable). Heterodimer with either TENM1 or TENM3. May also form heterodimer with TENM4 (By similarity). Isoform 2 (C-terminal globular domain) interacts with ADGRL1 isoform 2.Post-translational modification[Ten-2, soluble form]: Derives from the membrane form by proteolytic processing.; [Ten-2 intracellular domain]: Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway (By similarity).DomainEGTarget Relevance information above includes information from UniProt accession: Q9NT68The UniProt Consortium|