Name :
Recombinant Cynomolgus SLC39A6/LIV-1 Protein (His Tag)
Biological Activity :
Background :
Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. SLC39A6, also known as LIV-1, belongs to a new subfamily of Zrt, Irt-like protein zinc transporters (LZTs). It is involved in maintaining the intracellular homeostasis of zinc, an ion that is essential in the control of cellular growth and differentiation. SLC39A6 plays a critical role in maintaining zinc homeostasis, and was originally identified as an estrogen-induced gene in a breast cancer cell line. Generally, elevated SLC39A6 expression is reportedly related to cancer progression in other various types of cancer, including breast, prostate, pancreatic, cervical and liver cancers.
Biological Activity :
Immobilized Cynomolgus SLC39A6/LIV-1 His(Cat:90978-C08H) at 2 μg/mL (100 μL/well) can bind Rabbit Anti-SLC39A6/LIV-1 Antibody(Cat:203773-T08), the EC50 of Rabbit Anti-SLC39A6/LIV-1 Antibody(Cat:203773-T08) is 15-100 ng/mL.
Expression Host :
Cynomolgus
Source :
HEK293 Cells
Tag :
Protein Accession No. :
A0A2K5WH46-1
NCBI Gene ID :
Synonyms :
Synonyms :
solute carrier family 39 member 6
Amino Acid Sequence :
Molecular Weight :
The recombinant cynomolgus SLC39A6 consists of 299 amino acids and predicts a molecular mass of 34 kDa.
Purity :
> 95 % as determined by SDS-PAGE.
State of Matter :
Product Concentration :
Storage and Stability :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin Level :
< 1.0 EU per μg protein as determined by the LAL method.
Protein Construction :
A DNA sequence encoding the cynomolgus SLC39A6 (A0A2K5WH46-1) (Met1-Gln308) was expressed with a polyhistidine tag at the C-terminus.
Buffer Solution :
Lyophilized from sterile 20mM MES, 150 mM NaCl, 10%glycerol, 0.02% Tween 80, pH 6.0.Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Redissolution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Synonyms :
References & Citations :
Cui XB, et al. (2015) Slc39a6: A potential target for diagnosis and therapy of esophageal carcinoma. J Transl Med 13 321.
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