Thus, blockage of Hsp90 interferes with all anti-cancer mechanisms of 15d-PGJ2 and might be one explanation for the widespread activity of 15d-PGJ2 on tumor progression
Western blot investigation of Hsp90, nonetheless, did not assist this interpretation. 2nd-gel electrophoresis shown a profound modify of Hsp protein demand by a pI shift which indicates alterations in posttranslational…