examined the roles of the small Rab5 and Rab7 GTPases, known to be key regulators in vesicular trafficking to early and late endosomes, respectively. To this end, the DN mutants…
PC Function in vivo reendothelialization capacity. 3) Jasplakinolide downregulated the expressions of integrin b1, integrin b3, CXCR4 and SDF-1, but increased eNOS phosphorylation and NO production. 4) NO donor SNP…
tent of an important component of the sarcomere, the slow MHC protein. questioned in the hindlimb unloading animal model, several researchers have found that rodents supplemented with vitamin E, Bowman-Birk…
to H2O2, there was a significant increase in the phosphorylation of ASK1 compared with the control group. Pretreatment with either 50 or 400 mM 20E for 24 h before H2O2…
a heterogenous complement of TRPC subunits, as found also for other neuronal types. Our experiments using blocking antibodies confirmed the central role played by the TRPC1 subunit in the inward…
osely monitored with a rectal probe and maintained at 37.0 6 0.5uC with a heating pad during and after surgery until recovery from anesthesia. Transmission Electron Microscopy of Autophagosomes in…
t of myocardial fibers in comparison with that of sham group. Furthermore, electron microscopy detected the ultrastructural damages of cardiomyocytes such as detached and snapped myofibrils, intramitochondrial blebs and mitochondrial…
ECAM in native, methylamine-treated, and protease-activated forms by small angle X-ray scattering at physiological pH. ECAM changes conformation upon activation SAXS experiments were performed with four distinct samples: native ECAM,…
. Differences between samples were considered to be significant at P,0.05. ~~ Airway smooth muscle contraction is mainly controlled by autonomic neurons innervating the airways and the lung. The autonomic…
serum-containing media and coverslips were processed as above. GST-binding Assay GST binding assays were carried out as previously described. Briefly, U2OS cells were lysed in GST lysis buffer or vehicle…