Product Name: Rb (deltaRb-p70), cleavage-specific
Type: Mouse Monoclonal IgG1
Elisa:
WB: 1:250
Background: The retinoblastoma gene product (Rb) is a tumor suppressor protein that acts as cell cycle regulator and has roles in apoptosis. During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. Caspase-3 cleaves Rb into 48 and 68kDa fragments. Cl
CAS NO.: 130641-38-2
Bindarit
Immunogen: Clone 172C1094 was developed from a synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb. The sequence is well conserved in rat and mouse Rb.
Buffer And Storage: Mouse monoclonal antibody purified with protein G chromatography is supplied in 100µl phosphate-buffered saline, 0.05% BSA, and 0.05% sodium azide. Store at 4°C. For long term storage, store at –20°C.
Specificity: The antibody detects cleaved Rb (deltaRb-p70) at 68 kDa* in HL60 cells treated with camptothecin. The antibody does not detect full length Rb. RM4931 can be used for western blot and immunohistochemistry.
PubMed ID:http://aac.asm.org/content/51/3/839.abstract