Gnificant.Author Contributions: Conceptualization, J.M.K.; methodology, J.I.J.; software program, J.I.J.; validation, J.I.J. and J.M.K.; formal analysis, J.I.J., K.H.L. and J.M.K.; investigation, J.M.K.; sources, J.M.K. and K.H.L.; data curation, J.I.J., and J.M.K.; writing–original draft preparation, J.M.K.; writing–review and editing, J.M.K.; visualization, J.I.J.; supervision, J.M.K.; project administration, J.M.K.; funding acquisition, J.M.K. and K.H.L. All authors have read and agreed towards the published version on the manuscript. Funding: This study was supported by the basic Science Research System via the National Investigation Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technologies (MEST) (NRF-2021R1F1A1045550), Republic of Korea. Institutional Evaluation Board Statement: Not applicable. Informed Consent Statement: Not applicable. Conflicts of Interest: The authors have no conflict of interest to declare.International Journal ofMolecular SciencesReviewIntermolecular Diels-Alder Cycloadditions of Furfural-Based Chemical compounds from Renewable Resources: A Concentrate on the Regio- and Diastereoselectivity within the Reaction with AlkenesKonstantin I. Galkin 1,2 and Valentine P. Ananikov 1, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospekt 47, 119991 Moscow, Russia; [email protected] Laboratory of 1-Aminocyclopropane-1-carboxylic acid-d4 Endogenous Metabolite Functional Composite Materials, Bauman Moscow State Technical University, 2nd Baumanskaya Street 5/1, 105005 Moscow, Russia Correspondence: [email protected]: Galkin, K.I.; Ananikov, V.P. Intermolecular Diels-Alder Cycloadditions of Furfural-Based Chemicals from Renewable Sources: A Focus around the Regio- and Diastereoselectivity in the Reaction with Alkenes. Int. J. Mol. Sci. 2021, 22, 11856. ten.3390/ ijms222111856 Academic Editor: Vladim K en r Received: 14 October 2021 Accepted: 29 October 2021 Published: 1 NovemberAbstract: A current sturdy trend toward green and sustainable chemistry has promoted the intensive use of renewable carbon sources for the production of polymers, biofuels, chemicals, monomers and other useful solutions. The Diels-Alder reaction is of terrific importance in the chemistry of renewable resources and supplies an atom-economic pathway for fine chemical synthesis and for the production of components. The Averantin supplier biobased furans furfural and 5-(hydroxymethyl)furfural, which could be quickly obtained from the carbohydrate a part of plant biomass, have been recognized as “platform chemicals” that can support to replace the current oil-based refining to biorefining. Diels-Alder cycloaddition of furanic dienes with a variety of dienophiles represents the best example of a “green” procedure characterized by a 100 atom economy in addition to a reasonable E-factor. In this assessment, we very first summarize the literature information on the regio- and diastereoselectivity of intermolecular Diels-Alder reactions of furfural derivatives with alkenes together with the aim of establishing the current progress in the effective production of practically crucial low-molecular-weight solutions. The details supplied right here are going to be helpful and relevant to scientists in a lot of fields, such as medical and pharmaceutical analysis, polymer development and materials science. Keywords and phrases: biobased furans; renewable building blocks; plant biomass; Diels-Alder cycloaddition; selectivity; sustainable chemistry; biorefining1. Introduction To date, the improvement of efficient technologies for catalytic or biocatalytic conversion of renewable plant biomass into.