Diseases constituted 9 of all deaths among children <5 years old in 2015.4 Although the burden of diarrheal diseases is much lower in developed countries, it is an important public health problem in low- and middle-income countries because the disease is particularly dangerous for young children, who are more susceptible to dehydration and nutritional losses in those settings.5 In Bangladesh, the burden of diarrheal diseases is significant among children <5 years old.6 Global estimates of the mortality resulting from diarrhea have shown a steady decline since the 1980s. However, despite all advances in health technology, improved management, and increased use of oral rehydrationtherapy, diarrheal diseases are also still a leading cause of public health concern.7 Moreover, morbidity caused by diarrhea has not declined as rapidly as mortality, and global estimates remain at between 2 and 3 episodes of diarrhea annually for children <5 years old.8 There are several studies assessing the prevalence of childhood diarrhea in children <5 years of age. However, in Bangladesh, information on the age-specific prevalence rate of childhood diarrhea is still limited, although such studies are vital for informing policies and allowing international comparisons.9,10 Clinically speaking, diarrhea is an alteration in a normal bowel movement characterized by an increase in theInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh 2 University of Strathclyde, Glasgow, UK Corresponding Author: Abdur Razzaque Sarker, Health Economics and Financing Research, International Centre for Diarrhoeal Disease Research, 68, Shaheed Tajuddin Sarani, Dhaka 1212, Bangladesh. Email: [email protected] Commons Non Commercial CC-BY-NC: a0023781 This article is distributed beneath the terms from the Inventive Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits noncommercial use, reproduction and distribution from the work without having additional permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).2 water content material, volume, or frequency of stools.11 A lower in consistency (ie, soft or liquid) and an increase within the frequency of bowel movements to 3 stools per day have typically been applied as a definition for epidemiological investigations. According to a community-based study perspective, diarrhea is defined as no less than three or extra loose stools within a 24-hour period.12 A diarrheal episode is viewed as because the passage of 3 or a lot more loose or liquid stools in 24 hours before presentation for care, which can be considered by far the most practicable in children and adults.13 Having said that, prolonged and persistent diarrhea can last involving 7 and 13 days and at the very least 14 days, Indacaterol (maleate) respectively.14,15 The disease is highly sensitive to climate, displaying seasonal variations in many sites.16 The climate sensitivity of diarrheal illness is consistent with observations in the direct effects of climate variables on the causative agents. IKK 16 biological activity Temperature and relative humidity have a direct influence around the price of replication of bacterial and protozoan pathogens and on the survival of enteroviruses within the atmosphere.17 Well being care journal.pone.0169185 searching for is recognized to be a outcome of a complex behavioral procedure that is influenced by several things, including socioeconomic and demographic and characteristics, perceived need to have, accessibility, and service availability.Diseases constituted 9 of all deaths among children <5 years old in 2015.4 Although the burden of diarrheal diseases is much lower in developed countries, it is an important public health problem in low- and middle-income countries because the disease is particularly dangerous for young children, who are more susceptible to dehydration and nutritional losses in those settings.5 In Bangladesh, the burden of diarrheal diseases is significant among children <5 years old.6 Global estimates of the mortality resulting from diarrhea have shown a steady decline since the 1980s. However, despite all advances in health technology, improved management, and increased use of oral rehydrationtherapy, diarrheal diseases are also still a leading cause of public health concern.7 Moreover, morbidity caused by diarrhea has not declined as rapidly as mortality, and global estimates remain at between 2 and 3 episodes of diarrhea annually for children <5 years old.8 There are several studies assessing the prevalence of childhood diarrhea in children <5 years of age. However, in Bangladesh, information on the age-specific prevalence rate of childhood diarrhea is still limited, although such studies are vital for informing policies and allowing international comparisons.9,10 Clinically speaking, diarrhea is an alteration in a normal bowel movement characterized by an increase in theInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh 2 University of Strathclyde, Glasgow, UK Corresponding Author: Abdur Razzaque Sarker, Health Economics and Financing Research, International Centre for Diarrhoeal Disease Research, 68, Shaheed Tajuddin Sarani, Dhaka 1212, Bangladesh. Email: [email protected] Commons Non Commercial CC-BY-NC: a0023781 This article is distributed below the terms from the Inventive Commons Attribution-NonCommercial three.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits noncommercial use, reproduction and distribution in the work with no further permission provided the original perform is attributed as specified around the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).2 water content, volume, or frequency of stools.11 A decrease in consistency (ie, soft or liquid) and a rise within the frequency of bowel movements to three stools per day have frequently been made use of as a definition for epidemiological investigations. According to a community-based study perspective, diarrhea is defined as at least three or a lot more loose stools within a 24-hour period.12 A diarrheal episode is regarded as because the passage of three or extra loose or liquid stools in 24 hours prior to presentation for care, which can be thought of by far the most practicable in children and adults.13 However, prolonged and persistent diarrhea can last involving 7 and 13 days and no less than 14 days, respectively.14,15 The disease is extremely sensitive to climate, showing seasonal variations in a lot of sites.16 The climate sensitivity of diarrheal disease is constant with observations of the direct effects of climate variables on the causative agents. Temperature and relative humidity possess a direct influence on the price of replication of bacterial and protozoan pathogens and around the survival of enteroviruses within the atmosphere.17 Well being care journal.pone.0169185 looking for is recognized to be a outcome of a complex behavioral procedure that is certainly influenced by many variables, such as socioeconomic and demographic and qualities, perceived require, accessibility, and service availability.