Mines and male infertility. Hum Reprod Update. 2006;12(4):417?5. 130. Nanassy L, Liu L, Griffin J, Carrell DT. The clinical utility of the protamine 1/ protamine 2 ratio in sperm. Protein Pept Lett. 2011;18(8):772?. 131. de Yebra L, Ballesc?JL, Vanrell JA, Bassas L, Oliva R. Complete selective absence of protamine P2 in humans. J Biol Chem. 1993;268(14):10553?. 132. Aoki VW, Liu L, Carrell DT. Identification and evaluation of a novel sperm protamine abnormality in a population of infertile males. Hum Reprod. 2005;20(5):1298?06. 133. Aoki VW, Moskovtsev SI, Willis J, Liu L, Mullen JBM, Carrell DT. DNA integrity is compromised in protamine-deficient human sperm. J Androl. 2005;6(26):741?. 134. Simon L, Castillo J, Oliva R, Lewis SEM. Relationships between human sperm protamines, DNA damage and assisted reproduction outcomes. Reprod Biomed Online. 2011;23(6):724?4. 135. Takeda N, Yoshinaga K, Furushima K, Takamune K, Li Z, Abe S, Aizawa S, Yamamura K. Viable offspring obtained from Prm1-deficient sperm in mice. Sci Rep. 2016;2(6):27409. doi:10.1038/srep27409. 136. Perrin A, Caer E, Oliver-Bonet M, Navarro J, Benet J, Amice V, de Braekeleer M, Morel F. DNA fragmentation and meiotic segregation in sperm of carriers of a chromosomal structural abnormality. Fertil Steril. 2009;92(2):583?. 137. Carrell DT, Wilcox AL, Lowy L, Peterson CM, Jones KP, Erickson L, Campbell B, Branch DW, Hatasaka HH. Elevated sperm chromosome aneuploidy and apoptosis in patients with unexplained recurrent pregnancy loss. Obstet Gynecol. 2003;101(6):1229?5. 138. Muriel L, Goyanes V, Segrelles E, Gos vez J, Alvarez JG, Fern dez JL. Increased aneuploidy rate in sperm with fragmented DNA as determined by the sperm chromatin dispersion (SCD) test and FISH analysis. J Androl. 2007;28(1):38?9. 139. Enciso M, Alfarawati S, Wells D. Increased numbers of DNA-damaged spermatozoa in samples presenting an elevated rate of numerical chromosome abnormalities. Hum Reprod. 2013;28(6):1707?5. 140. Acloque H, Bonnet-Garnier A, Mompart F, Pinton A, Yerle-Bouissou M. Sperm nuclear architecture is locally modified in presence of a robertsonian translocation t(13;17). PLoS One. 2013;8(10):e78005. 141. McAuliffe ME, Williams PL, Korrick SA, Dadd R, Marchetti F, Martenies SE, Perry MJ. Human sperm sex chromosome disomy and sperm DNA damage assessed by the neutral comet assay. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25447644 Hum Reprod Oxf Engl. 2014;29(10):2148?5.142. Marchetti F, Bishop J, Gingerich J, Wyrobek AJ. Meiotic interstrand DNA damage escapes paternal repair and causes chromosomal aberrations in the zygote by maternal misrepair. Sci Rep. 2015;5:7689. 143. Conrad M, Moreno SG, Sinowatz F, Ursini F, K le S, Roveri A, Brielmeier M, Wurst W, Maiorino M, Bornkamm GW. The nuclear form of phospholipid hydroperoxide glutathione GDC-0084MedChemExpress RG7666 peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability. Mol Cell Biol. 2005;25(17):7637?4. 144. Noblanc A, Peltier M, Damon-Soubeyrand C, Kerchkove N, Chabory E, Vernet P, Saez F, Cadet R, Janny L, Pons-Rejraji H, Conrad M, Drevet JR, Kocer A. Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice. PLoS One. 2012;7(6):e38565. 145. Chabory E, Damon C, Lenoir A, Kauselmann G, Kern H, Zevnik B, Garrel C, Saez F, Cadet R, Henry-Berger J, Schoor M, Gottwald U, Habenicht U, Drevet JR, Vernet P. Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. J Clin Invest. 2009;119(7):2074?5. 146. Noblanc A,.