Oduce the new LAI antipsychotic just after the discontinuation of the existing LAI FGA or LAI SGA (when the time because the final injection corresponds towards the interval amongst two injections). In 2nd line tactic, the switch from the current LAI FGA or LAI SGA for the new LAI SGA is suggested straight soon after having provided an oral test dose of your newly introduced SGA LAI to be able to do away with any hypersensitivity. The initial dose for the oral kind or for the new LAI SGA will correspond (if feasible) to an equivalent dose in the preceding LAI FGA or LAI SGA (1st line strategy).Sensible procedures for the introduction and for the injection remindersIn order to assist with the acceptance and understanding on the rewards of an LAI treatment, it isLlorca et al. BMC Psychiatry 2013, 13:340 http:www.biomedcentral.com1471-244X13Page eight ofFigure 3 Graphic final results with the question about benefitrisk balance for LAI FGA and LAI SGA in schizophrenic sufferers.unanimously recommended by the authorities (technique of choice) to convey towards the patient specific data concerning both the benefits and inconveniences of your FGA and SGA LAI, which are becoming deemed, within the framework of shared decisionmaking. Through the introduction of your therapy, initiation in the LAI form is advised just before the finish of a full-time hospitalization for an acute episode (method of choice). Introduction of LAI antipsychotics can also be deemed throughout outpatient care (as 2nd line method). The 1st line tactic of performing the injections through the maintenance remedy in outpatients should be to coordinate the follow-up psychiatric consultations together with the dates from the injections. The injections can also be performed by a nurse inside a hospital day care unit or at house (as 1st line approach).Table eight Benefitrisk ratio for LAI FGA and LAI SGA in bipolar disorderPrevention of manic recurrence 1st-line remedy Prevention of depressive recurrence -Note: these injection procedures will not be applicable to FGFR4-IN-1 site olanzapine pamoate as this treatment requires distinct post-injection monitoring in a hospital. To be able to boost patient compliance, it really is recommended that the following reminder strategies are place in spot: 1st line techniques, employing phone reminders and agenda offered for the patient (follow-up diary). 2nd line methods, by letter or sooner or later by text messages. The prevention of local complications needs the injections to be performed: deep intramuscularly (gluteal or deltoid muscle) (technique of choice). by altering 
the injection website each and every time (as 1st line technique). by proposing a neighborhood transdermal anaesthetic (cream or patch) just before the injection in an effort to cut down the pain at the injection internet site (as 2nd line approach).Precise therapeutic methods according to the psychiatric disorder or its co-morbidities Schizophrenia and delusional chronic disorder2nd-line In monotherapy or in mixture Generally in combination therapy using a mood stabilizer with a mood stabilizer Risperidone LAI Olanzapine pamoate Risperidone LAI Olanzapine pamoateAcute psychotic episode with LAI FGA or LAI SGA remedy The relevant question from the survey using the experts’ answers are offered in Figure 4.Llorca et al. BMC PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21310317 Psychiatry 2013, 13:340 http:www.biomedcentral.com1471-244X13Page 9 ofFigure 4 Graphic outcomes in the query about therapeutic methods throughout an acute psychotic episode.- Within the acute phaseSeveral therapeutic adaptations are suggested as 1st line techniques: Optimization of.