Uccessively encouraged: in 1st line techniques. either to optimize the dose of your present oral antidepressant by rising the dose whilst monitoring tolerance. or to continue the mixture of a LAI SGA with an antidepressant and combination with an oral mood PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21310658 stabilizer with antidepressant impact. in 2nd line methods. either to combine a different oral antipsychotic using the existing LAI SGA. or to optimize the dose on the existing LAI SGA by rising the dose when monitoring tolerance. or to discontinue the current LAI SGA and switch to a bitherapy of oral mood stabilizers and oral antidepressant. or to continue the present therapy and ECT administration.- Immediately after stabilization with the depressive episodeIn the 1st line tactic, it really is suggested to continue as upkeep remedy the therapeutic method that permitted the reduction of symptoms and the stabilization from the clinical state (no precision of the duration). Within the 2nd line method, within the case on the mixture of an oral antidepressant with an LAI SGA in the acute phase, it really is advised to optimize the dose of your LAI SGA and to progressively discontinue the oral antidepressant, based on the clinical state.Psychiatric co-morbidities related using a schizophrenic or bipolar disorder with an LAI antipsychoticIt is advised to continue as upkeep therapy the therapeutic tactic that allowed the reduction of the symptoms plus the stabilization on the episode (no precision on the duration) (tactic of selection).Depressive bipolar episode with LAI SGA – Within the acute phaseManifestations of anxiousness (structured or non-structured) It is actually advised in 1st line therapy to associate an oral benzodiazepine, and in 2nd-line therapy to combine an antidepressant (as first-line therapy, an SSRI or SNRI).Addiction to a psychoactive substance (alcohol, opiates…)If monotherapy is ongoing, it is actually successively recommended: in 1st line technique: to combine the existing LAI SGA with an oral mood stabilizer with antidepressant effect (i.e. lamotrigine, quetiapine, lithium). in 2nd line approaches.Treatment by LAI SGA or LAI FGA might be continued. The prescription of opiate substitutes (buprenorphine or methadone) (1st line tactics) or disulfiram, acamprosate or naltrexone (2nd line approaches) based on the addiction, is achievable with LAI antipsychotics.Llorca et al. BMC Psychiatry 2013, 13:340 http:www.biomedcentral.com1471-244X13Page 11 ofProcedures for follow-up and monitoring Pre-therapeutic LAI antipsychotic summaryLAI antipsychotic and switch for the oral kind (at the minimum helpful dose).In the case of discovering a pregnancyAs 1st line strategies, it is suggested to systematically look for the following clinical GS-4059 hydrochloride web components: Personal and family medical history (diabetes, dyslipidaemia). Healthier way of life (consuming habits, physical activity, substance use, smoking). Weight, Body Mass Index calculation, umbilical circumference. Blood stress. It is suggested to carry out the following paraclinical checkups:1st line paraclinical exams:In the 1st2nd3rd trimester: The authorities failed to attain a consensus for 1st line tactics. As 2nd line tactics continuation of your LAI antipsychotic or switching to an oral type (FGA or SGA at the minimum powerful dose) is suggested.Elderly patientsComplete blood count, blood electrolyte (+ urea, creatinine, fasting glucose). Liver function tests. Lipid profile. Beta hCG. Electrocardiogram.The relevant query fr.