Individuals presenting suicidal behavior for the duration of acute episodes. Patients presenting a higher level of insight about their illness. A higher level of insight concerning the illness can be an indication for proposing an LAI SGA as a 2nd line treatment.Llorca et al. BMC Psychiatry 2013, 13:340 http:www.biomedcentral.com1471-244X13Page 7 ofLAI FGA are usually not suggested in cases 
of higher levels of insight concerning the illness.Bipolar disorderBenefitrisk balance for LAI FGA and LAI SGA based on the psychiatric disorderThe preferential BI-9564 biological activity selection criteria for an LAI formulation (as 1st line therapy) in bipolar sufferers are: Patients presenting poor adherence with nonacceptance of a long-term oral treatment. LAI SGA are advised as a 1st line therapy (in monotherapy or in mixture). Patients wishing for an LAI SGA remedy andor getting a history of productive therapy with LAI SGA for bipolar disorder symptoms. Irrespective in the clinical predicament, LAI FGA are under no circumstances advisable as maintenance treatment for bipolar disorder. The specialists failed to reach a favorable consensus for the preferential use of a LAI formulation (as 1st line therapy) for the following groups. They just specified the preferential category of LAI (FGA or SGA) for these groups. Patient presenting particular clinical qualities. Owing to the drugs currently out there, LAI SGA are suggested (as 2nd line treatment) in individuals presenting a type I bipolar disorder andor a predominant manic polarity andor speedy cycles. Patients presenting a risky behavior or even a history of impulsive behavior. LAI SGA are advised as 2nd line treatment. Individuals presenting a low degree of insight about the need to have for remedy. LAI SGA are suggested as 2nd line therapy.Table 7 Benefitrisk ratio for LAI FGA and LAI SGA in schizophreniaPrevention of psychotic recurrence 1st line treatment 2nd line remedy Risperidone LAI Olanzapine pamoate Haloperidol decanoate Zuclopenthixol decanoate Flupentixol decanoate Fluphenazine decanoate Pipotiazine palmitateIn individuals with schizophrenia The assessment with the benefitrisk ratio for each LAI formulation in the preventive remedy of psychotic recurrence is presented in Table 7. PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21310491 The relevant question from the survey with the experts’ answers are offered in Figure 3. The molecule ranking appears to be straight linked towards the tolerance level for every single LAI antipsychotic. LAI SGA are suggested as 1st line remedy except for olanzapine pamoate. In sufferers with bipolar disorder Only two LAI SGA are encouraged as 2nd line treatment: risperidone microsphere and olanzapine pamoate (Table 8). LAI FGA are contraindicated as maintenance remedy of bipolar disorder.Procedures for prescribing and use Sufferers stabilized by an antipsychotic treatmentSwitch from an oral form antipsychotic (FGA or SGA) to an LAI form First-line strategy will be to start using the antipsychotic oral kind for the length of time required to obtain an efficient dose and excellent tolerance just before switching towards the LAI type. Note. Only risperidone microspheres possess the pharmacokinetic traits that imperatively need an initial oral supplement. The prescription of LAI SGA should be created whilst taking into account the pharmacokinetic characteristics of each and every item. The dose on the introduced LAI type will correspond for the equivalent from the used oral dose (tactic of option). Switch from an LAI antipsychotic (FGA or SGA) to one more LAI antipsychotic First-line tactic is always to intr.