Oduce the new LAI antipsychotic after the discontinuation of the present LAI FGA or LAI SGA (when the time because the last injection corresponds to the TCS 401 interval involving two injections). In 2nd line tactic, the switch from the existing LAI FGA or LAI SGA for the new LAI SGA is recommended directly just after obtaining given an oral test dose of your newly introduced SGA LAI in order to do away with any hypersensitivity. The initial dose for the oral type or for the new LAI SGA will correspond (if probable) to an equivalent dose in the prior LAI FGA or LAI SGA (1st line strategy).Sensible procedures for the introduction and for the injection remindersIn order to help with the acceptance and understanding of your benefits of an LAI therapy, it 
isLlorca et al. BMC Psychiatry 2013, 13:340 http:www.biomedcentral.com1471-244X13Page 8 ofFigure 3 Graphic benefits with the question about benefitrisk balance for LAI FGA and LAI SGA in schizophrenic individuals.unanimously advisable by the specialists (approach of option) to convey for the patient specific info concerning both the positive aspects and inconveniences from the FGA and SGA LAI, which are becoming regarded as, within the framework of shared decisionmaking. Throughout the introduction on the remedy, initiation of the LAI form is advised just before the finish of a full-time hospitalization for an acute episode (technique of decision). Introduction of LAI antipsychotics may also be viewed as throughout outpatient care (as 2nd line method). The 1st line tactic of performing the injections through the upkeep therapy in outpatients would be to coordinate the follow-up psychiatric consultations using the dates from the injections. The injections may also be performed by a nurse in a hospital day care unit or at dwelling (as 1st line strategy).Table eight Benefitrisk ratio for LAI FGA and LAI SGA in bipolar disorderPrevention of manic recurrence 1st-line treatment Prevention of depressive recurrence -Note: these injection procedures are usually not applicable to olanzapine pamoate as this treatment demands particular post-injection monitoring in a hospital. In an effort to enhance patient compliance, it can be advised that the following reminder strategies are put in location: 1st line techniques, utilizing phone reminders and agenda provided towards the patient (follow-up diary). 2nd line methods, by letter or eventually by text messages. The prevention of regional complications demands the injections to become performed: deep intramuscularly (gluteal or deltoid muscle) (strategy of option). by altering the injection website each time (as 1st line strategy). by proposing a neighborhood transdermal anaesthetic (cream or patch) prior to the injection to be able to decrease the discomfort in the injection web page (as 2nd line technique).Precise therapeutic tactics as outlined by the psychiatric disorder or its co-morbidities Schizophrenia and delusional chronic disorder2nd-line In monotherapy or in combination Always in combination remedy using a mood stabilizer with a mood stabilizer Risperidone LAI Olanzapine pamoate Risperidone LAI Olanzapine pamoateAcute psychotic episode with LAI FGA or LAI SGA treatment The relevant question in the survey with the experts’ answers are offered in Figure four.Llorca et al. BMC PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21310317 Psychiatry 2013, 13:340 http:www.biomedcentral.com1471-244X13Page 9 ofFigure 4 Graphic results with the question about therapeutic approaches for the duration of an acute psychotic episode.- Within the acute phaseSeveral therapeutic adaptations are advisable as 1st line techniques: Optimization of.