The present LAI antipsychotic. either dose optimization on the existing LAI FGA or LAI SGA by rising the dose even though monitoring tolerance. or for LAI FGA: reduction of the time amongst 2 injections. Mixture of an oral antipsychotic together with the present LAI antipsychotic. The discontinuation of the existing LAI antipsychotic along with the switch to an oral antipsychotic inside the acute phase is only recommended as 2nd line approach.- Immediately after stabilization on the psychotic episodeIn the case from the mixture of an oral antipsychotic and an LAI antipsychotic in the acute phase, optimizing the dose in the LAI antipsychotic and progressively discontinuing the oral antipsychotic when monitoring the clinical state is suggested because the 1st line method.Residual symptoms with LAI antipsychotics justifying a reassessmentIt 
is successively advised: in 1st line strategies: to optimize the remedy by LAI FGA or LAI SGA. by dose optimization with the present LAI antipsychotic by rising the dose though monitoring tolerance. or for LAI FGA: by decreasing the time amongst 2 injections. in 2nd line methods. either via a mixture of an oral antipsychotic with all the existing LAI antipsychotic. or by changing the current LAI FGA or LAI SGA for yet another LAI antipsychotic (preferably a LAI SGA).It can be advised to continue as maintenance therapy the therapeutic tactic that allowed the reduction of symptoms as well as the stabilization in the episode (technique of decision). In the case of a switch to an oral antipsychotic treatment during the acute phase, switching to an LAI formulation as maintenance remedy is advisable because the 1st line method.Llorca et al. BMC Psychiatry 2013, 13:340 http:www.biomedcentral.com1471-244X13Page ten ofBipolar disorder Manic episode with LAI SGA-In the acute phase PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21310042 If monotherapy is ongoing, it truly is successively encouraged: in 1st line strategy: to combine the current LAI SGA with an oral anti-manic mood stabilizer (without the need of recommendation of a certain medication). in 2nd line approaches. to optimize the dose on the current LAI SGA by rising the dose though monitoring tolerance. or to SGC707 cost discontinue the present LAI SGA and switch to an oral anti-manic mood stabilizer (without the need of recommendation of a precise medication). If bitherapy is ongoing (LAI SGA + lithium or anticonvulsant), it’s successively advised: in 1st line tactic: to optimize the dose of the oral anti-manic mood stabilizer. in 2nd line tactics. either to combine the present LAI SGA with another oral anti-manic mood stabilizer (with no recommendation of a certain medication). or to optimize the dose of the existing LAI SGA by increasing the dose when monitoring tolerance. or to discontinue the existing LAI SGA and switch to a bitherapy of oral anti-manic mood stabilizers (without having recommendation of a precise medication). or to continue the current remedy and combination with a 2nd oral anti-manic mood stabilizer (devoid of recommendation of a specific medication). or to continue the present therapy and electroconvulsive therapy (ECT) administration.- Right after stabilization on the manic episode either to optimize the dose of your current LAI SGA by escalating the dose although monitoring tolerance. or to combine the present LAI SGA with an oral antidepressant or with a series of ECT. or to discontinue the existing LAI SGA and switch to an oral mood stabilizer with antidepressant effect. If bitherapy is ongoing (LAI SGA + antidepressant), it truly is s.