Bility from Mgchloride, Mgl-lactate and Mg-aspartate was equivalent [115](Table four) contd….Intestinal Absorption and Aspects Influencing Bioavailability of MagnesiumCurrent Nutrition Meals Science, 2017, Vol. 13, No.SpeciesDesignDurationType of Mg2+ Salt/Formulation DosesMg2+-Intake on or with DietAssessment/AdjustBefore InterventionControl of Mg2+ in Diet Throughout Treatment/Intervention PeriodTarget Parameter for Mg2+ Bioavailability Mg-citrate and MgMg excretion2+Empty Stomach ment of Mg2+-StatusCore ResultRefs.Randomized, 46 Healthful Adults parallelgroup, placebocontrolled, doubleblind 60 days3 Mg2+ salts: 1) 2694.four mg/d Mg2+ as Mg-amino acid chelate two) 2558.3 mg/d Mg2+ as Mg-citrate 3) 2809.8 mg/d Mg2+ as Mg-oxide 2 Mg2+ salts: With usual diet Subjects have been asked to avoid Mg rich foods Subjects had been asked to avoid Mg wealthy foods (no control)amino-acid chelate showed significantly greater absorption than Mg-oxide [113]in 24-h urine Mg2+ in saliva and plasma16 Healthier AdultsCross-over (5 days wash-out)10 days strict diet regime with Sober 350 mg Mg , very first 3 days + 300 mg Mgcitrate2+Mg2+ excretion Standardized diet (350 mg Mg2+) in 24h urine Mg2+ in plasma Mg2+ excretion No substantial differences [117]Single intake1) 600 mg Mg-oxide 2) 600 mg Mg-hydroxide carbonate20 Wholesome Male AdultsRandomized, cross-over2 Mg2+ salts: Single intake 1) Mg citrate two) Mg oxide With dietin 24-h urine, Supplementation with Mg2+ to saturate Mgpools (5 days) Balanced, mixed diet (300400 mg Mg/d) Mg in serum, red blood cells, leukocytes2+Mg-citrate showed higher absorption than Mg-oxide [116]6 Mg2+ salts: 1) Mg-carbonate: two.8 mg Mg2+/d two) Mg-chloride: two.7 mg Mg2+/d 120 Male SpragueDawley Rats Parallelgroup 2 weeks three) Mg-oxide: 2.eight mg Mg2+/d 4) Mg-phosphate: 2.5 mg Mg2+/d 5) Mg-sulfate: 2.6 mg Mg2+/d 6) Mg-silicate: two.6 mg Mg2+/d eight Mg2+ salts: 1) Handle: four.0 mg Mg2+/100 g 19.0 mg Mg2+/100 g (210) two) wheat flour 80 SpragueDawley Rats Parallelgroup, controldiet 4 weeks 3) Mg-sulfate four) Mg-oxide five) Mg-chloride six) Mg-phosphate 7) Mg-carbonate 8) Mg-lactate 9) Mg-citrate ten) Mg-acetate With diet 5993-18-0 Formula program No information and facts (“normal Mg2+-status”) Yes, identical mild Mg2+deficient diet program Mg2+ excretion in faeces and urine, Mg2+ in plasma No important differences [119] With eating plan 5-day pretest period with 9 g diet program each day (400 mg Mg /kg) 8 g diet program each day during the experimental period (200 or 400 mg Mg2+/kg) Yes, same diet2+Mg2+ excretion in faeces and urine, Mg2+ in plasma No significant Dimethomorph web variations [118](Table 4) contd….Current Nutrition Food Science, 2017, Vol. 13, No.Schuchardt and HahnSpeciesDesignDurationType of Mg2+Mg2+-Intake on or with DietAssessment/AdjustBefore InterventionControl of Mg2+ in Diet program In the course of Treatment/Intervention PeriodTarget Parameter for Mg2+ Bioavailability Core Result Refs.Salt/Formulation DosesEmpty Stomach ment of Mg2+-Status1 Mg salt: 1) Handle: 10.7.7 mg Mg2+/d two) Mg-chloride: 12.five.two 40 Male Wistar Rats Parallelgroup, controldiet 4 weeks mg Mg2+/d three) sulphate wealthy water: 13.7.2 mg Mg2+/d four) carbonate wealthy water: 13.six.0 mg Mg2+/d Day 24: 3 mg of Mg intravenously 10 Mg2+ salts: 600 mg Mg2+/kg eating plan for two weeks + 1.eight mg26 26 2+2+Mg2+ excretion in faeces and urine, With eating plan No info Yes, identical diet Mg2+ in plasma, red blood cells No substantial differences [120]orally + 0.5 mg 25MgMg2+Organic Mgsalts have been Mg2+ excretion Run in phase: three w 150 With diet program mg Mg2+/kg diet plan Yes, very same diet regime in faeces and urine, Mg2+ in plasma slightly more offered than inor.