2021, 26, x FOR PEER Assessment Molecules 2021, 26, x FOR PEER Critique Molecules 2021, 26, x
2021, 26, x FOR PEER Review Molecules 2021, 26, x FOR PEER Evaluation Molecules 2021, 26, x FOR PEER REVIEWMolecules 2021, 26,4 of 34 4 of 34 four of4 of15 15 Table 1. Cont.Entry Ar-XC (24 h) C (24 h) C (24 h)Method (Reaction Time)1f, 97 1f, 97 1f,Item (E), Yield 16 1716 1616 17 1717 18 1818 1918 1919 20 2020 21 2121 21 22 22B (24 h) B (24 h) C B (24 h) (48 h)h) B (24 C (48 h) C (48 h) C (48 h) C (48 h) C (48 h) C (48 D C (48 h) (24 h)h) D (24 h) D (24 h) C (48 h) C (48 D C (48 h) (24 h)h) D(24 h) D (24 h) D (24 D (24 h) D (24 h) D (24 D (24 h)1g, 37 1g, 1g, 37 1g, 9237 1g, 37 1g, 1g, 9292 1g, 92 1h, 80 1h, 1h, 80 1h, 80 1h, 8080 1h, 80 1h, 80 1i, 75 1i, 75 1i, 75 1i, 35 1i, 3535 1i, 1i, 35 1j, 35 1j, 1j, 3535 1j,Just after purification (see experimental component); when low yields were recorded, beginning supplies 1 1 Immediately after purification (see experimental low yields have been recorded, have been components had been generally recovered. 1 Soon after purification (see experimental part); when low yields had been recorded, starting components Immediately after normally recovered. had been purification (see experimental part); whenpart); when low yieldsstarting recorded, starting materials have been generally recovered. had been in general recovered.Regarding the double N-arylation reaction amongst 7-azaindole and and 1,3-diiodobenConcerning the double N-arylation reaction involving 7-azaindole 1,3-diiodobenzene, Concerning the the anticipated solution 2k with a2k withyield (40 ) than(40 ) than MethodMethod provideddouble N-arylation reaction among 7-azaindole and 1,3-diiodobenC also C also provided the anticipated product higher a Combretastatin A-1 In stock larger yield Approach D zene, Regarding the double N-arylation reaction among 7-azaindole and 1,3-diiodobenzene, D (15 ).C also supplied the expected productof four days, larger resultingresult(15 ). Even so,C also provided the anticipated item 2k using a higher yield2k from zene, Method despite long reaction occasions of four days, the product product (40 ) than Technique System Even so, despite long reaction instances 2k with a the2k yield (40 ) than Technique D (15 ). Nonetheless, is still extended reaction times of 4 days, both cases) 1, resultaing from a single Streptonigrin In Vitro N-arylationdespitepresent (isolated in 20 each circumstances) (Scheme(Scheme single N-arylation continues to be present (isolated in 20 yield in yield within the solution 2ktop). System D (15 ). Having said that, despite long reaction instances of 4 days, the solution 2k resultBying from contrast,N-arylation continues to be presentthe to the in 20 yield7-azaindole and 1,4contrast, single when C was C was applied reaction involving in each instances) (Scheme 1, major). By a when Method Technique applied to (isolated reaction in between 7-azaindole and diiodobenzene, the the anticipated product was this time obtained having a a higher 80 yield 1, top). By contrast, when Technique C was2l was this timereaction among 7-azaindole and 1, top). By contrast, when Approach C 2l applied to the obtained with higher 80 yield 1,4-diiodobenzene, anticipated item was applied for the reaction between 7-azaindole and 1,4-diiodobenzene, (Scheme 1, bottom). the anticipated product 2l was this time obtained with a high 80 yield 1,4-diiodobenzene, (Scheme 1, bottom). the expected item 2l was this time obtained having a high 80 yield (Scheme 1, bottom). (Scheme 1, bottom).Scheme 1. 1-Arylation reactions amongst 7-azaindole and 1,3- or 1,4-diodobenzene. Scheme 1. 1-Arylation reactions involving 7-azaindole and 1,3- or 1,4-diodobenzene. Scheme 1. 1-Arylation reactions in between 7-azaindole and 1,3- or 1,4-diodobenzene. Scheme 1. 1-A.