The skin wound tissues on days 3, five, and 7 soon after trauma. The outcomes are shown in Figure 1C. On day three soon after wound tissues on days three, 5, and 7 right after trauma. The results are shown in Figure 1C. On day 3 following trauma, the -SMA expression was weak in all wounds. The density of -SMA in the tissue of each and every trauma, the -SMA expression was weak in all wounds. The density of -SMA inside the tissue of each and every wound FGF-9 Proteins supplier steadily increased until day 5 just after trauma soon after which it steadily decreased to day 7 just after wound steadily improved till day 5 right after trauma immediately after which it steadily decreased to day 7 following trauma. quantitative evaluation from the -SMA optical density values the skin wound tissue at each trauma. A quantitative evaluation in the -SMA optical density values for for the skin wound tissue at time point are shown in Figure 1D; no considerable differences had been located identified amongst the peptide each and every time point are shown in Figure 1D; no important variations had been amongst the control,control, SIKVAV, chitosan, chitosan, and Integrin alpha V beta 8 Proteins supplier chitosan + chitosan groups on day 3 post-trauma. Nevertheless, the peptide SIKVAV, and SIKVAV + SIKVAV groups on day three post-trauma. Having said that, the optical density of -SMA in the -SMA in the the wounds chitosan group was significantly was substantially optical density ofskin wounds of skinSIKVAV +of the SIKVAV + chitosan group greater than those of the than these on days 5 and 7 following on days 5 and 7 significant variations were observed higher other groups of your other groups trauma; statisticallyafter trauma; statistically significant among the SIKVAV group along with the chitosan group at any time point. variations had been observed amongst the SIKVAV group along with the chitosan group at any time point.Figure 1. SIKVAV-modified chitosan hydrogel promotes the contraction of skin wounds in mice: Figure 1. AA SIKVAV-modifiedchitosan hydrogel promotes the contraction of skin wounds in mice: (A) Standard photoimages of your wounds wounds SIKVAV, chitosan, and chitosan, and (A) Typical photoimages of your common common of manage, of control, SIKVAV, SIKVAV-modified chitosan group mice on days three, five, and on days 3, five, and 7 Statistical evaluation from the analysis with the SIKVAV-modified chitosan group mice 7 after trauma. (B)soon after trauma. (B) Statisticalresidual wound percentage of micepercentage ofSIKVAV,within the control, SIKVAV, chitosan, and SIKVAV-modified residual wound in the manage, mice chitosan, and SIKVAV-modified chitosan groups (n = 6, p 0.05, and p groups (n Immunohistochemistry 0.01). (C) Immunohistochemistry showing wounds of the chitosan 0.01). (C)= 6, p 0.05, and p displaying the expression of -SMA in the skinthe expression handle, SIKVAV, chitosan, and SIKVAV-modified SIKVAV, chitosan, and SIKVAV-modified chitosan of -SMA in the skin wounds of your control,chitosan group mice on days three, 5 and 7 after trauma (scale bar: 50 ). (D) Statistical analysis of -SMA within the skin wounds of Statistical control, of -SMA within the group mice on days three, 5 and 7 following trauma (scale bar: 50 m). (D) mice in theanalysis SIKVAV, chitosan, and wounds of mice chitosan groups on days chitosan, and SIKVAV-modified chitosan p 0.01). skin SIKVAV-modified in the manage, SIKVAV,three, five and 7 right after trauma (n = 3, p 0.05, and groups on3.2. The SIKV AV-Modified Chitosan Hydrogel Accelerated Skin Wound Re-Epithelializationdays 3, five and 7 immediately after trauma (n = three, p 0.05, and p 0.01).3.2. The SIKVAV-Modified Chitosan Hydrogel Accelerated Skin Wound Re-Epithelialization center.