Conceptual structure evaluation utilizing MCA (Figure 3) showed that most reports on ENDS and HTPs are grouped into 3 categories: in vitro analysis, which consists of terms for example cell-line and epithelial cells; animal models, which contains terms like mice and lung; and human studies, like males, females, and young adults. We use these categories to group the findings within the revised articles.Int. J. Environ. Res. Public BChE Inhibitor Formulation Wellness 2021, 18,Int. J. Environ. Res. Public Overall health 2021, 18, x3 of3 ofprocess followed the PRISMA recommendations (Preferred Reporting Things for Systematic critiques four of 14 Int. J.Figure 1. The post selection18, x Environ. Res. 1. The report selection method followedthe PRISMAguidelines (Preferred Reporting Items for Systematic evaluations Figure Public Well being 2021, and Meta-Analyses) [19]. and Meta-Analyses) [19].The bibliometric evaluation discovered 3 key hierarchical subjects. We grouped the keyword phrases into three clusters and ran the MCA evaluation with 20 words across all articles readily available to look for relationships in more than 80 in the literature H-Ras Inhibitor supplier reviewed (Figure 2). The conceptual structure evaluation applying MCA (Figure 3) showed that most reports on ENDS and HTPs are grouped into 3 categories: in vitro evaluation, which includes terms which include cell-line and epithelial cells; animal models, which contains terms including mice and lung; and human studies, such as males, females, and young adults. We make use of these categories to group the findings in the revised articles.Figure 2. Evaluation with the conceptual structure by topic dendrogram determined three hierarchical categories on the keywords and phrases Figure 2. Analysis with the conceptual structure by topic dendrogram determined 3 hierarchical categories of your keywords and phrases inincluded within the articles analyzed. Green = human research; blue = animal models; red = in vitro research. cluded within the articles analyzed. Green = human research; blue = animal models; red = in vitro research.Figure two. Evaluation from the conceptual structure by topic dendrogram determined 3 hierarchical categories of your key phrases incorporated in the articles analyzed. Green = human research; blue = animal models; red = in vitro studies.Int. J. Environ. Res. Public Wellness 2021, 18,four ofFigure three. Conceptual structure obtained by several correspondence analysis with the search phrases analyzed. analyzed. Figure 3. Conceptual structure mapmap obtained by many correspondence evaluation of the keywords Dim = diDim = dimension; Green studies; research; blue models; models; red = in vitro mension; Green = human= humanblue = animal = animalred = in vitro research. studies.3.1. In Vitro Models 3.1. In Vitro Models Most research in vitro utilize immortal cell lines from distinctive parts with the lung Most research in vitro utilize immortal cell lines from distinct parts of your lung (bron(bronchial epithelium, lung fibroblast); this can be a broadly applied model as a result of its low chialand comfort. fibroblast);this model at times model due to its low cost and price epithelium, lung Nonetheless, this can be a broadly applied supplies varying results, as some comfort. Nevertheless, this modelin immortalization usually interfere with a number of the with the cellular pathways involved sometimes delivers varying final results, as biomarkers cellular pathways involved in immortalization have a tendency toMore recent research have opted for released in inflammation and DNA harm [224]. interfere with biomarkers released in inflammation and DNA harm [224]. Moreobtained from healt.