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Phillips et al. BMC Pregnancy and Childbirth 2014, 14:241 ARTICLEOpen AccessProstaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially impacted by preterm and term labour and by uterine inflammationRobert J Phillips1, Michel A Fortier2 and Andr L ez Bernal1,3*AbstractBackground: Elucidation with the biochemical pathways involved in activation of preterm and term human labour would facilitate the improvement of efficient management and inform judgements regarding the necessity for preterm tocolysis and post-term induction. Prostaglandins act at all stages of human reproduction, and are potentially activators of labour. Procedures: Expression of 15 genes involved in prostaglandin synthesis, transport and degradation was measured by qPCR working with tissue samples from human placenta, amnion and choriodecidua at preterm and full-term vaginal and caesarean delivery. Cellular localisation of eight prostaglandin pathway proteins was determined by immunohistochemistry. Outcomes: Expression of prostaglandin pathway genes was differentially impacted by things including gestational age at delivery, plus the incidence and duration of labour. Chorioamnionitis/deciduitis was related to upregulation of PTGS2 (prostaglandin-endoperoxide synthase two (prostaglandin.