Es, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia?2013 Phang et al.; licensee BioMed Central Ltd. This can be an Open Access write-up distributed below the terms of your Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, SSTR2 Activator Compound supplied the original operate is correctly cited.Phang et al. BMC Complementary and Option Medicine 2013, 13:243 biomedcentral/1472-6882/13/Page 2 ofBackground Alpinia species, in the Zingiberaceae household have already been extensively studied for their chemical and biological properties [1]. Primarily based around the ethnobotanical research, lots of species of this genus have been made use of in traditional medicine, and in the preparations and flavorings of food in several Asian nations. Amongst the Alpinia species, the rhizomes of Alpinia galanga have been widely employed as spice and inside the therapy of stomachic in China and Thailand; coughs, asthma, bronchitis, headache, inflammation, rheumatoid arthritis and colic in Malaysia [2,3]. One wild species, Alpinia mutica has been employed to treat stomach upset by natives and it has also been reported to show good antioxidant and cytotoxic anticancer properties [4]. A few novel compounds isolated from the species of Alpinia had been identified to have anti-cancer, antiinflammatory, anti-spasmodic, anti-ulcerogenic, neuroprotective, analgesic, hepatoprotective and cardioprotective properties [5]. Due to its wide therapeutic values, it is actually of terrific interest to conduct extra studies around the unexplored species from this genus which may possibly possess medicinal properties, but has not been totally studied. Within this endeavour, Alpinia pahangensis was hence chosen for investigation. Alpinia pahangensis, a wild ginger, occcuring significantly less common inside the genus, is really a perennial plant distributed inside the lowlands of Pahang, Malaysia. The rhizomes of A. pahangensis happen to be utilized by tribal natives for relieving flatulence. However, there’s a limited study on the biological activity of your A. pahangensis. A recent report by Awang et al. [6] SSTR2 Agonist site showed that the crucial oil extracted from the rhizomes and leaves of Alpinia pahangensis had good antimicrobial activity against Staphylococcus aureus strains and chosen fungi. Cost-free radicals produced in our body resulting from aerobic respiration and substrate oxidation, may cause oxidative pressure which may perhaps contribute for the improvement of a number of diseases like cancer, Alzheimer’s illness, aging, diabetes, Parkinson disease and atherosclerosis [7-13]. Overproduction of totally free radicals in our bodies could possibly be increasing on account of pollution along with other external variables, and their removal by our antioxidant systems can be decrease than before on account of quite a few components connected to our life style among other individuals. Oxidative stress causes significant harm to significant cellular macromolecules including protein and DNA. However, the production of totally free radicals may be balanced by antioxidant actions of endogenous enzymes also as all-natural and synthetic antioxidants [14,15]. Antioxidants exert its action through quite a few mechanisms including prevention of chain initiation, chelating of transition metal ion catalysts, decomposition of peroxidases, prevention of continued hydrogen abstraction and radical scavenging [16].These deleterious effects of cost-free radicals have drawn the attentions of scientists for the value of antioxidants in prevention and treatment of diseases [17]. Therefore, there has been increasing interest.