Product Name :
GNE-317
Synonym :
Chemical Name :
CAS NO.:
1394076-92-6
Molecular formula :
C19H22N6O3S
Molecular Weight:
414.48 g/mol
Classification :
MedChemExpress Products > Life Sciences > GNE-317
Description:
GNE-317 is a cancer therapeutic that inhibits the activity of CDK4/6 and is currently in phase II clinical trials. GNE-317 has been shown to be effective in inhibiting tumor growth in mice with metastatic melanoma. The mechanism of action of GNE-317 is by binding to CDK4/6 and inhibiting their activity, which prevents phosphorylation of effector proteins such as S6 kinase. This inhibition leads to a decrease in cell proliferation and an increase in apoptosis.GNE-317 has been shown to inhibit the growth of human breast cancer cells without affecting normal cells. It also inhibits Hdac, a protein involved in cell signaling pathways that can lead to uncontrolled cell growth, which may be due to its ability to inhibit histone deacetylation.
Purity :
>98%
Specifications :
10 mM * 1 mL
Price.:
105
Price unit :
$
Inventory :
In stock
Related websites: https://www.medchemexpress.com
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