Product Name :
AES-135
Description:
AES-135, a hydroxamic acid-based HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM.
CAS:
2361659-61-0
Molecular Weight:
693.66
Formula:
C33H29F6N3O5S
Chemical Name:
4-{N-[(4-tert-butylphenyl)methyl]-2-{N-[(2,3,4,5,6-pentafluorophenyl)methyl]4-fluorobenzenesulfonamido}acetamido}-N-hydroxybenzamide
Smiles :
CC(C)(C)C1C=CC(CN(C2C=CC(=CC=2)C(=O)NO)C(=O)CN(CC2C(F)=C(F)C(F)=C(F)C=2F)S(=O)(=O)C2C=CC(F)=CC=2)=CC=1
InChiKey:
LTRKEOBJRDKIHB-UHFFFAOYSA-N
InChi :
InChI=1S/C33H29F6N3O5S/c1-33(2,3)21-8-4-19(5-9-21)16-42(23-12-6-20(7-13-23)32(44)40-45)26(43)18-41(48(46,47)24-14-10-22(34)11-15-24)17-25-27(35)29(37)31(39)30(38)28(25)36/h4-15,45H,16-18H2,1-3H3,(H,40,44)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AES-135, a hydroxamic acid-based HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM.|Product information|CAS Number: 2361659-61-0|Molecular Weight: 693.66|Formula: C33H29F6N3O5S|Chemical Name: 4-{N-[(4-tert-butylphenyl)methyl]-2-{N-[(2,3,4,5,6-pentafluorophenyl)methyl]4-fluorobenzenesulfonamido}acetamido}-N-hydroxybenzamide|Smiles: CC(C)(C)C1C=CC(CN(C2C=CC(=CC=2)C(=O)NO)C(=O)CN(CC2C(F)=C(F)C(F)=C(F)C=2F)S(=O)(=O)C2C=CC(F)=CC=2)=CC=1|InChiKey: LTRKEOBJRDKIHB-UHFFFAOYSA-N|InChi: InChI=1S/C33H29F6N3O5S/c1-33(2,3)21-8-4-19(5-9-21)16-42(23-12-6-20(7-13-23)32(44)40-45)26(43)18-41(48(46,47)24-14-10-22(34)11-15-24)17-25-27(35)29(37)31(39)30(38)28(25)36/h4-15,45H,16-18H2,1-3H3,(H,40,44)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (144.{{Glycine} MedChemExpress|{Glycine} iGluR|{Glycine} Protocol|{Glycine} Formula|{Glycine} manufacturer|{Glycine} Epigenetic Reader Domain} 16 mM; Need ultrasonic).{{Gotistobart} medchemexpress|{Gotistobart} Immunology/Inflammation|{Gotistobart} Technical Information|{Gotistobart} In Vitro|{Gotistobart} supplier|{Gotistobart} Cancer} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24120168 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AES-135 inhibits cancer cells growth with IC50 values of 2.3 µM, 1.4 µM, 0.27 µM, 0.94 µM, 1.9 µM, 2.72 µM, 2.1 µM, 15.0 µM, 1.6 µM and 19.2 µM for BT143, BT189, D425, D458, MV4-11, MOLM-13, MDA-MB-231, K562, PC-3 and MRC-9 cells, respectively.|In Vivo:|AES-135 (50 mg/kg; intraperitoneal injection; 5 days a week; for 1 month) treatment significantly increases survival of C57Bl/6 mice implanted with KPC2 cells. NSG mice are dosed with a single 20 mg/kg intraperitoneal (IP) injection, and blood is taken at 0.5 h, 1 h, 2 h, 4 h, 8 h, and 24 h. AES-135 achieved μM concentrations in the blood, reaching Cmax 7452 ng/mL (10.74 μM) within 30 min, which is sustained for 8 h. The blood concentration of AES-135 is dose dependent, achieving an average of 323 ng/mL (0.47 μM) with 10 mg/kg dosing and 1829 ng/mL (2.64 μM) with 40 mg/kg. AES-135 shows an impressive pharmacokinetic profile in mice with an in vivo half-life of 5.0 h.|Products are for research use only. Not for human use.|