Product Name :
PHT-7.3
Description:
PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity.
CAS:
1614225-93-2
Molecular Weight:
433.52
Formula:
C24H23N3O3S
Chemical Name:
4-[(1,3-dioxan-2-yl)methyl]-2-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-1,2-dihydrophthalazin-1-one
Smiles :
CC1C=CC(=CC=1)C1=CSC(CN2N=C(CC3OCCCO3)C3=CC=CC=C3C2=O)=N1
InChiKey:
AFPMVLVIYVAFSP-UHFFFAOYSA-N
InChi :
InChI=1S/C24H23N3O3S/c1-16-7-9-17(10-8-16)21-15-31-22(25-21)14-27-24(28)19-6-3-2-5-18(19)20(26-27)13-23-29-11-4-12-30-23/h2-3,5-10,15,23H,4,11-14H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity.|Product information|CAS Number: 1614225-93-2|Molecular Weight: 433.52|Formula: C24H23N3O3S|Chemical Name: 4-[(1,3-dioxan-2-yl)methyl]-2-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-1,2-dihydrophthalazin-1-one|Smiles: CC1C=CC(=CC=1)C1=CSC(CN2N=C(CC3OCCCO3)C3=CC=CC=C3C2=O)=N1|InChiKey: AFPMVLVIYVAFSP-UHFFFAOYSA-N|InChi: InChI=1S/C24H23N3O3S/c1-16-7-9-17(10-8-16)21-15-31-22(25-21)14-27-24(28)19-6-3-2-5-18(19)20(26-27)13-23-29-11-4-12-30-23/h2-3,5-10,15,23H,4,11-14H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 62.{{Amrubicin} site|{Amrubicin} Topoisomerase|{Amrubicin} Technical Information|{Amrubicin} Formula|{Amrubicin} supplier|{Amrubicin} Epigenetics} 5 mg/mL (144.{{Moxifloxacin} MedChemExpress|{Moxifloxacin} Antibiotic|{Moxifloxacin} Technical Information|{Moxifloxacin} In Vitro|{Moxifloxacin} supplier|{Moxifloxacin} Epigenetics} 17 mM; Need ultrasonic).PMID:32644421 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|PHT-7.3 (200 mg/kg; i.p.; daily; for 20 days) exhibits cytostatic antitumor activity in the mut-KRas(G12S) A549 xenograft and mut-KRasG12V H441 xenograft.|Products are for research use only. Not for human use.|