Product Name :
6RK73
Description:
6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer.
CAS:
1895050-66-4
Molecular Weight:
307.37
Formula:
C13H17N5O2S
Chemical Name:
(3S)-1-cyano-N-[5-(morpholin-4-yl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide
Smiles :
N#CN1C[C@H](CC1)C(=O)NC1=NC=C(S1)N1CCOCC1
InChiKey:
ONIHSXKWNFYNNS-JTQLQIEISA-N
InChi :
InChI=1S/C13H17N5O2S/c14-9-17-2-1-10(8-17)12(19)16-13-15-7-11(21-13)18-3-5-20-6-4-18/h7,10H,1-6,8H2,(H,15,16,19)/t10-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer.|Product information|CAS Number: 1895050-66-4|Molecular Weight: 307.37|Formula: C13H17N5O2S|Chemical Name: (3S)-1-cyano-N-[5-(morpholin-4-yl)-1,3-thiazol-2-yl]pyrrolidine-3-carboxamide|Smiles: N#CN1C[C@H](CC1)C(=O)NC1=NC=C(S1)N1CCOCC1|InChiKey: ONIHSXKWNFYNNS-JTQLQIEISA-N|InChi: InChI=1S/C13H17N5O2S/c14-9-17-2-1-10(8-17)12(19)16-13-15-7-11(21-13)18-3-5-20-6-4-18/h7,10H,1-6,8H2,(H,15,16,19)/t10-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (406.{{Floxuridine} site|{Floxuridine} Anti-infection|{Floxuridine} Purity & Documentation|{Floxuridine} Data Sheet|{Floxuridine} supplier|{Floxuridine} Cancer} 68 mM; Need ultrasonic).{{Desloratadine} site|{Desloratadine} Neuronal Signaling|{Desloratadine} Biological Activity|{Desloratadine} References|{Desloratadine} custom synthesis|{Desloratadine} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32964807 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|6RK73 (5 µM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells. 6RK73(5 µM; 24-48 hours) results migration significantly slower than the DMSO control group in MDA-MB-436 cells.|In Vivo:|6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish.|Products are for research use only. Not for human use.|